Curated Database of Human
lncRNA–disease
A manually curated database of long non-coding RNA records with documented associations to human disease, verified from peer-reviewed literature.
What is a lncRNA & lncRNA2DB?
1. What is a lncRNA?
Long non-coding RNAs (lncRNAs) are a class of non-protein-coding RNA transcripts exceeding 200 nucleotides in length. Unlike messenger RNAs (mRNAs), lncRNAs do not translate into proteins; instead, they fold into highly complex 3D structures that function as molecular scaffolds, epigenetic modifiers, and gene expression regulators in human cells.
2. About lncRNA2DB
lncRNA2DB is a specialized bioinformatics database developed and maintained by the Bioinformatics Infrastructure Facility (BIF) Centre at the University of Kalyani. It catalogues experimentally validated lncRNA–disease associations with full genomic coordinates, GC content, transcript lengths, binding partners, and PubMed publication provenance.
3. Validated Examples
- BACE1-AS (chr11): Antisense lncRNA that stabilizes BACE1 mRNA to drive amyloid-β accumulation in Alzheimer's Disease.
- HOTAIR (chr12): Represses transcription by scaffolding histone methyltransferases in Breast & Colorectal Cancers.
- MALAT1 (chr11): Regulates alternative splicing and nuclear speckle dynamics in Lung Adenocarcinoma.
BIF Centre, University of Kalyani
The Bioinformatics Infrastructure Facility (BIF) Centre at the University of Kalyani is a research unit dedicated to computational biology and bioinformatics. Established under the Department of Biotechnology (DBT), Government of India, the centre supports research in genomics, proteomics, and systems biology.
lncRNA2DB is developed and maintained as part of the centre's mission to provide open-access bioinformatics resources to the global research community.
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